The consumption of a Med-diet appears to be independently associated with cardiometabolic risk after adjustment for adiposity 5. For the outcome variables in our mediation analyses, fasting insulin, HOMA-IR, fasting glucose, postload glucose, and HbA1c were selected as markers for insulin resistance; hs-CRP, white blood cell WBC count, fibrinogen, homocysteine, and lipoprotein a were selected for inflammatory markers. Finally, a total of individuals were analyzed in the present study Supplemental Figure 1. Acknowledgements The authors gratefully acknowledge the participants who participated in the study. Cite this article Stanton, A. Mediation analysis could clarify the role of adiposity underlying the relation between Med-diet intake and cardiometabolic risk 6. The natural indirect effect is the contrast, having set the Med-diet intake at the level of the highest tertile, between the counterfactual outcome if BMI assumed whatever value it would have taken at a value of the highest tertile of Med-diet intake and the counterfactual outcome if BMI assumed whatever value it would have taken at a reference value of the lowest tertile of Med-diet intake. Anwar T Merchant. Natural indirect effect.
Background: The inverse association between Mediterranean diet Med-diet consumption and insulin resistance or inflammatory markers is well known. However, the extent to which obesity may act directly on or mediate this association is unclear. Objective: We aimed to investigate whether the associations between Med-diet consumption and markers of insulin resistance and inflammation are mediated by body mass index BMI or waist circumference WC in a representative US population. Methods: We used cross-sectional data from adults aged 20—90 y without any previous diagnosis of cancer, cardiovascular disease, diabetes, or hypertension based on the NHANES III, — Linear regression models were fitted in conventional and causal mediation analyses comparing extreme MDS tertiles. The mediated effects of WC were consistently greater than those of BMI for all markers in both conventional and causal mediation analyses. Conclusion: Our results suggest that reducing abdominal obesity may play an important role in the pathway through which Med-diet consumption reduces insulin resistance and inflammation.
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Adherence to a Mediterranean Diet MedDiet is inversely associated with sarcopenia. The aim of this study was to examine the association between adherence to a MedDiet and sarcopenic symptomology in obese older adults. Sixty-five older adults were included. Future research should investigate whether a Mediterranean-style intervention can prevent or improve sarcopenic symptomology, including in non-Mediterranean populations. This is a preview of subscription content, log in to check access. Rent this article via DeepDyve.